PROJECT TITLE Enhancing anti-cancer therapies with botanicals
CATEGORY Breast Cancer, Botanicals
PROJECT 
DESCRIPTION
Most single cancer drugs do not kill all of a patient's cancer cells. Combination cancer therapies destroy more cancer cells, but significantly increase treatment side effects. This research project seeks to combine current effective cancer drugs with botanical medicines, to achieve the combined destruction of cancer cells without an increase in side effects. 

These researchers have shown that a combination of the botanical medicine Huanglian with Taxol (a breast cancer chemotherapy) led to a doubling of cell death compared to Taxol alone. In separate studies, they have documented that concurrent use of this botanical medicine and Adriamycin (a cancer chemotherapy) led to 100% remission of cancer in animal models. 

Botanicals have been used for centuries, their safety is known, they have few side effects, and they are relatively inexpensive.  However, because there is little profit potential in the medical discoveries related to these non-patentable compounds, scientific research is not funded, even though these compounds show great promise in helping to cure patients.   With the insight and hard work at Memorial Sloan-Kettering and the funding of committed donors, we will see that these botanical medicines are tested and that validated information is distributed to patients and their physicians.

INVESTIGATORS Barrie Cassileth, Ph.D., Frank M. Sirotnak, Ph.D., Andrew J. Vickers, Ph.D. 
CO-FUNDERS Memorial Sloan Kettering, Laurance S. Rockefeller Foundation, International Breast Cancer Research Foundation
INSTITUTION Memorial Sloan-Kettering Cancer Center
1275 York Ave.
New York, NY 10021
STATUS Research project began July 1, 2004