|
|
|
| PROJECT TITLE | Enhancing anti-cancer therapies with botanicals |
| CATEGORY | Breast Cancer, Botanicals |
| PROJECT DESCRIPTION |
Most single cancer drugs do not kill all of a patient's cancer cells.
Combination cancer therapies destroy more cancer cells, but significantly
increase treatment side effects. This research project seeks to combine current
effective cancer drugs with botanical medicines, to achieve the combined destruction of
cancer cells without an increase in side effects.
These researchers have shown that a combination of the botanical medicine Huanglian with Taxol (a breast cancer chemotherapy) led to a doubling of cell death compared to Taxol alone. In separate studies, they have documented that concurrent use of this botanical medicine and Adriamycin (a cancer chemotherapy) led to 100% remission of cancer in animal models. Botanicals have been used for centuries, their safety is known, they have few side effects, and they are relatively inexpensive. However, because there is little profit potential in the medical discoveries related to these non-patentable compounds, scientific research is not funded, even though these compounds show great promise in helping to cure patients. With the insight and hard work at Memorial Sloan-Kettering and the funding of committed donors, we will see that these botanical medicines are tested and that validated information is distributed to patients and their physicians. |
| INVESTIGATORS | Barrie Cassileth, Ph.D., Frank M. Sirotnak, Ph.D., Andrew J. Vickers, Ph.D. |
| CO-FUNDERS | Memorial Sloan Kettering, Laurance S. Rockefeller Foundation, International Breast Cancer Research Foundation |
| INSTITUTION |
Memorial Sloan-Kettering Cancer Center 1275 York Ave. New York, NY 10021 |
| STATUS | Research project began July 1, 2004 |